Intercellular communications-redox interactions in radiation toxicity; potential targets for radiation mitigation

Strategies for prediction and mitigation of radiation-induced liver toxicity

Although well described in the 1960s, liver toxicity secondary to radiation therapy, commonly known as radiation-induced liver disease (RILD), remains a major challenge. RILD encompasses two distinct clinical entities, a 'classic' form, composed of anicteric hepatomegaly, ascites and elevated alkaline phosphatase; and a 'non-classic' form, with liver transaminases elevated to more than five tim...

Late radiation toxicity in Hodgkin lymphoma patients: proton therapy's potential

In 2010, all young patients treated for intrathoracic Hodgkin lymphoma (HL) at one of 10 radiotherapy centers in the province of Quebec received 3D conformal photon therapy. These patients may now be at risk for late effects of their treatment, notably secondary malignancies and cardiac toxicity. We hypothesized that more complex radiotherapy, including intensity-modulated proton therapy (IMPT)...

Low toxicity radiation sensitizer

Potential treatments for radiation dermatitis.

Radiation therapy used alone or in combination with chemotherapy and/or surgery for the treatment of cancer can be extremely problematic and painful to the patient. The adverse effects of radiation therapy include dryness, itching, peeling, or blistering of the skin. There are numerous formulas and compounds that can be utilized to help patients with radiation burns. The compounding pharmacist,...

IN TRAOPERATIVE RADIATION THERAPY FOR GASTRIC ADENOCARCINOMA

Intraoperative radiation therapy (IORT) is a multidisciplinary approach in which residual tumors or tumor beds are directly irradiated during a surgical procedure. To evaluate its efficacy, from 1985, we conducted a prospective study including non-metastatic gastric adenocarcinoma treated by surgery, IORT (15 Grays) and postoperative external beam radiotherapy (44 Grays). Up to 1993, 51 ca...